Stop Flozins in Patients Who Complain About Ketoacidosis Symptoms

July 2015

See updated FDA information (December 2015) concerning SGLT2 inhibitors (Flozins) and ketoacidosis/urinary tract infections.

Colleagues will ask you whether Invokana (canagliflozin) and other SGLT2 inhibitors or "flozins" are linked to ketoacidosis.

This seems to be a flozin class effect...and has researchers scratching their heads about the mechanism.

It's different from the ketoacidosis we typically see with VERY high blood glucose. It's often happening in patients with blood glucose levels near normal or only slightly elevated.

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